Multilingual abstracts in the five official working languages of the united nations. This article is from nature communications, volume 5. Surveys of human fecal samples have frequently reported o. Opisthorchis viverrini medigoo health medical tests and. Opisthorchiasis is a parasitic disease caused by species in the genus opisthorchis specifically, opisthorchis viverrini and opisthorchis felineus. Opisthorchis viverrini, a parasitic trematode, was recategorized as a group 1 biological carcinogen because it causes opisthorchiasis, which may result in cholangiocarcinoma. Foodborne trematodes, opisthorchis viverrini, opisthorchiasis prevention. Opisthorchis viverrini, common name southeast asian liver fluke, is a trematode parasite from the family opisthorchiidae that attacks the area of the bile duct. If the inline pdf is not rendering correctly, you can download the pdf file here. Risk factors for opisthorchis viverrini infection in. The opisthorchis viverrini genome provides insights into.
Jul 18, 2018 the liver flukes, opisthorchis viverrini and clonorchis sinensis, are known to cause cholangiocarcinoma cca, a type of liver cancer that develops within the bile duct. Trematodes flukes opisthorchis viverrini southeast asian liver fluke and opisthorchis felineus cat liver fluke. Opisthorchis viverrini, a foodborne trematode parasite endemic in the lower mekong countries, is conventionally diagnosed by stool examination. Opisthorchis viverrini is a zoonotic liver fluke that causes opisthorchiasis among humans in endemic areas, such as northeastern thailand. A new strategy for controlling opisthorchiasis is needed because of issues such as drug resistance and reinfection. Liver flukes infect the liver, gallbladder, and bile duct in humans. People are infected after eating raw or undercooked fish. Ov, is a serious health problem of northeast, thailand.
First report and molecular identification of opisthorchis. There have been national campaigns in place aimed at the control and eradication of soiltransmitted helminthiasis and opisthorchiasis in thailand for several decades. Opisthorchis viverrini wikipedia, a enciclopedia livre. Opisthorchis felineus an overview sciencedirect topics. These pathogen safety data sheets, regulated under workplace hazardous materials information system whmis legislation, are produced for personnel working in the life sciences as quick safety reference material relating to infectious microorganisms. Pdf fish sharing as a risk factor for opisthorchis viverrini infection. Efficacy and safety of tribendimidine against opisthorchis viverrini. Opisthorchis viverriniis a food borne trematode, important because of the sheer numbers of people infected and its serious morbidities. Infection with the parasite is called opisthorchiasis. Chronic infection may lead to cholangiocarcinoma, a.
Opisthorchis viverrini, opisthorchis felineus and clonorchis sinensis 1. The carcinogenic liver fluke opisthorchis viverrini is a reservoir for species of helicobacter asian pac j cancer prev, 16 5, 17511758 introduction cholangiocarcinoma cca is highly prevalent in asian. Infection with opisthorchis viverrini and its associated cholangiocarcinoma cca is an underestimated problem in the mekong region of southeast asia, despite the widespread use of praziquantel and health education measures for parasite control. Opisthorchis viverrini is remains a public health problem in thailand, particularly in the northeast and north region where has the high incident of chonalgiocarcinoma cca. Prevalence of opisthorchis viverrini infection and incidence. Opisthorchis viverrini description, causes and risk factors. Opisthorchiasis is an infection caused by either of the two parasite worms, the cat liver fluke, or scientifically called opisthorchis felineus also known as opisthorchis tenuicollis, or the southeast asian liver fluke called as opisthorchis viverrini. Pdf opisthorchis viverrini and opisthorchiasis banchob. The trematode opisthorchis viverrini is a fishborne fluke that is commonly transmitted by ingesting raw fish containing infective metacercariae that excyst in the duodenum and migrate to the bile ducts. Opisthorchis viverrini is found in thailand and surrounding countries in southeast asia, whereas opisthorchis felineus is reported from eastern europe, siberia, and the european union. Thinking beyond opisthorchis viverrini for risk of.
Opisthorchis species are liver fluke parasites that humans can get by eating raw or undercooked fish, crabs, or crayfish from areas in asia and europe where the parasite is found. Pcr diagnosis of opisthorchis viverrini and haplorchis. The carcinogenic liver fluke opisthorchis viverrini is a. Opisthorchiasis and opisthorchisassociated cholangiocarcinoma in.
Prevalence and associated risk factors of opisthorchis viverrini infections in rural communities along the nam kam river of northeastern thailand chuangchaiya, s. Population structure of opisthorchis felineus trematoda. Opisthorchiasis is caused by opisthorchis viverrini southeast asian liver fluke and o. Opisthorchiasis is a neglected, tropical disease caused by the carcinogenic asian liver fluke, opisthorchis viverrini. Pdf opisthorchis viverrini and opisthorchis felineus researchgate. Opisthorchiasis viverrini is a common infection of the civet cat and other fisheating mammals, such as domestic cats and dogs reservoir final hosts, in cambodia. Fish sharing as a risk factor for opisthorchis viverrini. Opisthorchis viverrini infection among migrant workers in. Definitive diagnosis of infection is usually achieved parasitologically through the discovery of fluke eggs in feces. Opisthorchis viverriniis a food borne trematode, important because of the sheer numbers of people infected and its serious morbidities such as hepatobiliary diseases and cholangiocarcinoma. They have a knob at the abopercular end that may be prominent, inconspicuous, or absent. Residents of 20 districts in the province were invited to attend a mobile screening programme between 1990 and 2001. Opisthorchiasis is a parasitic disease that can infect fish eating mammals, including humans.
In thailand and neighbouring countries, human opisthorchiasis is caused by o. A crosssectional study of 403 immigrant workers was conducted between october 2016 and june 2017 in nakhon ratchasima, thailand. Frontiers granulin secreted by the foodborne liver. Ele vive no figado humano, sendo encontrado principalmente nas vias biliares e vesicula biliar, alimentase da bile. Opisthorchiasis, caused by the liver fluke opisthorchis viverrini, is a major risk factor for cholangiocarcinoma 1. The adult flukes deposit fully developed eggs that are passed in the feces. Morfologicamente e muito semelhante ao opistorchis felineus, embora ligeiramente menor. Select up to three search categories and corresponding keywords using the fields to the right. The tumorigenic liver fluke opisthorchis viverrini. Microproteinuria during opisthorchis viverriniinfection.
A biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasis prasert saichua1, paiboon sithithaworn2,3, amar r. The liver fluke opisthorchis viverrini is a foodborne, zoonotic pathogen endemic to thailand and adjacent countries in southeast asia. Liver fluke infection caused by opisthorchis viverrini is a major public health problem in thailand and adjacent countries. Two important helminths, strongyloides stercoralis an intestinal roundworm and opisthorchis viverrini a liver fluke, are endemic in northeast thailand. Risk factors for opisthorchis viverrini infection in nakhon phanom. Opisthorchis viverrini ov, a human liver fluke, is a pathologically and economically important foodborne trematode. Foodborne trematodiasis fbt is a significant global health problem, with the liver flukes opisthorchis viverrini, o. First report and molecular identification of opisthorchis viverrini infection in human communities from lower myanmar plos one, dec 2019 win pa pa aung, thi thi htoon, htay htay tin, kyi kyi thinn.
Imported opisthorchis viverrini and parasite infections from thai labourers in taiwan volume 67 issue 2 h. However, these helminths still exist and raise concerns regarding public. In like fashion, diabetes mellitus is a major public health problem in this region and worldwide. Opisthorchis viverrini infection in the snail and fish. Rapid labelfree analysis of opisthorchis viverrini eggs. This study is a crosssectionalanalytic study, aimed to determine actual levels of o. Media in category opisthorchis viverrini the following 7 files are in this category, out of 7 total.
Genetic variation in opisthorchis viverrini trematoda. Prevalence and associated risk factors of opisthorchis. Apr 29, 2004 opisthorchis viverrini ov, a liver fluke, is endemic in the area, and has been evaluated as a cause of chca by international agency for research on cancer. To combat and eventually eliminate the transmission of the liver fluke opisthorchis viverrini, an accurate and practical diagnostic test is required. Pdf opisthorchis viverrini and opisthorchis felineus. Numerous public health interventions have focused on reducing exposure to o. Although data from cambodia, laos and vietnam are rare, data from thailand often show wideranging. The goal of this study was to develop the immunodiagnosis of opisthorchiasis using cathepsin f cysteine protease of o. Welcome to cdc stacks adult opisthorchis viverrini. Publishers pdf, also known as version of record citation for published version apa.
Permission is granted to copy, distribute andor modify this document under the terms of the gnu free documentation license, version 1. Opisthorchis viverrini is a serious problem in thailand, cambodia, the lao peoples democratic republic and vietnam. Liver flukes, such as clonorchis sinensis or opisthorchis viverrini, usually enter humans gastrointestinal tract after ingestion of raw fish or drinking of contaminated water. Pdf on jan 1, 2014, paiboon sithithaworn and others published opisthorchis viverrini and. Infection is acquired when people ingest raw or undercooked fish. Pdf opisthorchiasis caused by opisthorchis viverrini remains a major public health problem in many parts of southeast asia, including. Opisthorchis viverrini is known as the southeast asian liver fluke and o. Efficacy and safety of tribendimidine versus praziquantel. Opisthorchis viverrini, in the lower mekong region. Opisthorchis viverrini infection is highly prevalent in northeast thailand. Nakhon phanom province had the highest prevalence of o. Agent orange exposure cholangiocarcinoma bile duct liver.
Files are available under licenses specified on their description page. In vitro diagnostic for the liver flukes opisthorchis. Infection with opisthorchis viverrini and its associated cholangiocarcinoma cca is an underestimated problem in the mekong region of southeast asia, despite the widespread use of praziquantel and. A total of 75 fecal specimens were analyzed by pcr following dna extraction. Current high prevalences of strongyloides stercoralis and. Opisthorchis viverrini is found mainly in northeast thailand, laos, cambodia, and central and southern vietnam. Opisthorchis species are liver fluke parasites that humans can get by eating raw or undercooked fish, crabs, or crayfish from areas in asia and europe where the parasite is found, including thailand, laos, cambodia, vietnam, germany, italy, belarus, russia, kazakhstan, and ukraine. The opisthorchis viverrini genome provides insights into life. Welcome to cdc stacks adult opisthorchis viverrini flukes. A polymerase chain reaction pcr assay was evaluated for detection of opisthorchis viverrini eggs in the stool specimens of light and heavily infected individuals in khon kaen province of thailand. Treatment of the liver fluke infection opisthorchis viverrini relies exclusively on praziquantel. Molecular changes in opisthorchis viverrini southeast asian liver. These species of flukes are classified as group i carcinogens by the international agency for research on cancer iarc.
Infection with opisthorchis viverrini and its associated cholangiocarcinoma cca is an underestimated problem in the mekong region of southeast asia, despite the widespread use of praziquantel. Affected individuals often have mixed infections with the liver fluke opisthorchis viverrini and minute intestinal flukes such. We performed an epidemiologic survey of opisthorchiasis in yangon, myanmar. We aimed to assess the efficacy and safety of a single, oral dose of tribendimidine, compared with praziquantel administered in two doses, in participants with o viverrini infection. Opisthorchis viverrini and clonorchis sinensis a opisthorchis viverrini thailand is the most endemic country for opisthorchiasis due to o. Comparing the performance of urine and coproantigen. Opisthorchiasis caused by opisthorchis viverrini is a serious health issue in the mekong basin region, resulting in a high prevalence of cholangiocarcinoma. Author summary opistorchis viverrini is an important and neglected parasite affecting.
Liver fluke infection caused by opisthorchis viverrini is a major public. However, parasitological stoolbased diagnosis can be unreliable in light infections. Parasites travel via the duodenum into the hosts intrahepatic or extrahepatic biliary ducts. Deimert4, jiraporn sithithaworn5, banchob sripa6, thewarach laha2, eimorn mairiang7, chawalit pairojkul7, maria victoria periago8. Opisthorchis viverrini is a food borne trematode, important because of the sheer numbers of people infected and its serious morbidities such as hepatobiliary diseases and cholangiocarcinoma chca. Abstractopisthorchiasis is a neglected, tropical disease caused by the carcinogenic asian liver fluke. Opisthorchiasis is a major public health problem in southeast asia.
In addition to infectionassociated morbidity, infection with o. Secreted cysteine proteases of the carcinogenic liver fluke, opisthorchis viverrini. Please see additional file 1 for translations of the abstract into the five official working languages of the united nations. Opisthorchis viverrini, common name southeast asian liver fluke, is a foodborne trematode parasite from the family opisthorchiidae that infects the bile duct. Liver flukes are platyhelminth parasites of the class trematoda, and opisthorchis viverrini o viverrini is a member of the family opisthorchiidae. Secreted cysteine proteases of the carcinogenic liver fluke. Opisthorchis viverrini an overview sciencedirect topics.
A recently established urine antigen detection test using monoclonal antibodybased enzymelinkedimmunosorbent assay mabelisa has shown promise due to its high diagnostic accuracy and the use of urine in place of fecal samples. The three epidemiologically important opisthorchiidae liver flukes opisthorchis felineus, o. Research open access mothers opisthorchis viverrini. The tumorigenic liver fluke opisthorchis viverrini multiple pathways.
Chronic infection may lead to cholangiocarcinoma, a malignant cancer of the bile ducts. The carcinogenic liver fluke opisthorchis viverrini is a reservoir for species of helicobacter asian pac j cancer prev, 16 5, 17511758 introduction cholangiocarcinoma cca is highly prevalent in asian countries, particularly in thailand, china, taiwan and korea shin et al. Posterior probability pp support for each of these major clades was 1. This hepatobiliary disease is linked to malignant cancer. Please see additional file 1 for translations of the abstract.
May 14, 2014 opisthorchis viverrini is highly endemic in southeast asia, where more than 10 million people are infected 1, 2. T cell deprivation appeared to have no effect on worm establishment or egg production. Lowgrade endemicity of opisthorchiasis, yangon, myanmar. Opisthorchis viverrini ov infection is one of the foodborne trematodiases, which is highly endemic in lao peoples democratic republic pdr. The interrelationships of these two conditions were investigated in hamsters and in tissue cultures of. Opisthorchis and metorchis, commonly referred to as liver flukes, are transmitted to humans and other mammals by the ingestion of fish infected with their larval stages which. Cooccurrence of opisthorchiasis and diabetes exacerbates. The carcinogenic liver fluke opisthorchis viverrini is a reservoir for species of helicobacter quantitative real time pcr h. All structured data from the file and property namespaces is available under the. Opisthorchis viverrini is notable, because it is classi. Opisthorchis felineus has been documented in at least 12 countries of the european union, belarus, ukraine, and in western siberia russia. Fish intermediate hosts of the liver flukes a opisthorchis viverrini. Opisthorchis viverrini has a complex life cycle in which eggs are excreted in the feces of the final hosts, usually humans, with cats and more rarely dogs also acting in this role 6, 12. In 198081, the prevalence in the north, northeastern, centre.
Imported opisthorchis viverrini and parasite infections. Opisthorchis viverrini, adult worm image from ash, 1997. Author summary infection with the foodborne liver fluke opisthorchis viverrini frequently causes bile duct cancer, a prominent public health concern in the greater mekong subregion countries. Adult opisthorchis felineus major protein fractions deduced. Fish sharing as a risk factor for opisthorchis viverrini infection. A biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasis prasert saichua1, paiboon sithithaworn2,3. Suppression of aquaporin, a mediator of water channel control.
Opisthorchis viverrini genome provides insights into life in the bile duct. Refer to the help section for more detailed instructions. Repeated praziquantel treatment and opisthorchis viverrini infection. Opisthorchis viverrini infection in the snail and fish intermediate. Endemicity of opisthorchis viverrini liver flukes, vietnam.
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